O'Brien's Cafe prides itself on a diverse menu that excels in breakfast offerings. The selection includes traditional favorites, like fluffy pancakes, crispy bacon, and classic omelettes, as well as local specialties that are unique to the area. Highlights include a variety of burritos, especially the breakfast burrito, which comes highly recommended and is known for its satisfying portions. Comfort food reigns supreme, with dishes such as chicken fried steak and homemade meatloaf drawing both locals and newcomers.

Health-conscious diners find appealing choices among the small plates and vegetarian options, along with a dedicated kids menu featuring familiar favorites tailored for young taste buds. The dessert category, though limited, showcases house-made options that promise to end any meal on a sweet note. Despite the myriad of choices, O'Brien's maintains a straightforward approach, ensuring that each dish is made fresh and to perfection. This locally-loved cafe is a testament to hearty, home-style cooking that feels like dining at Grandma’s, right in the heart of Sedalia.